ADAM33遺伝子の関連性は,喘息と支障管の過敏反応と関連している
Paul Van Eerdewegh1, Randall D Little, Josée Dupuis
1Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA.
Nature
|July 12, 2002
まとめ
遺伝的要因は,喘息の発症に大きく寄与する. この研究では,クロモソーム20p13の特定の遺伝子であるADAM33を特定し,白人の家族における喘息と支氣管の過敏反応と強く関連付けました.
科学分野:
- 遺伝学 遺伝学とは
- 呼吸器医学とは
- 分子生物学は分子生物学である.
背景:
- 喘息は,環境的および遺伝的要因の両方によって影響される一般的な呼吸器疾患です.
- 以前の関連研究では,多数のゲノム領域が喘息の感受性に関与していることが判明しました.
- 双子や家族に関する研究により,強い遺伝的要素が示唆されている.
研究 の 目的:
- 喘息の感受性に関連した特定の遺伝子を特定する.
- ブロンキーの過敏反応性の遺伝的基礎を調査する.
- 喘息の病原性におけるADAM33の役割を調査する.
主な方法:
- 460の白人家族の全ゲノムスキャン.
- 関連したゲノム領域を特定するためのリンク分析.
- 症例対照,伝播不均衡,および23の遺伝子におけるポリモルフィズムに関するハプロタイプ分析を含む関連研究.
- 候補遺伝子を特定するためのポジショナルのクローニング.
主要な成果:
- 染色体20p13 (LOD 2.94) にある重要な喘息感受性位置が特定されました.
- この同じ位置は, bronchial hyperresponsiveness (LOD 3.93) との強い関連性を示した.
- ADAM33遺伝子は喘息と有意に関連していることが判明しました (P = 0.04 - 0.000003).
結論:
- ADAM33は,推定的な喘息感受性遺伝子である.
- ADAM33の識別は,喘息の病原性についての洞察を提供します.
- ADAM33のさらなる特徴化は,喘息の自然経歴を明らかにする可能性がある.
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