アディポネクチンとピマ・インディアンの2型糖尿病の発生
Robert S Lindsay1, Tohru Funahashi, Robert L Hanson
1National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA. rlindsay@mail.nih.gov
Lancet (London, England)
|July 13, 2002
まとめ
肥満に関連するタンパク質であるアディポネクチンのレベルが低下すると,2型糖尿病のリスクが予測されます. アディポネクチン濃度が高い個人は,この代謝障害を発症する可能性が低いことを示しました.
科学分野:
- メタボリック疾患の研究
- エンドクリノロジー エンドクリノロジー
- 肥満に関する研究.
背景:
- アディポネクチンは,脂肪組織によって分泌されるタンパク質ホルモンです.
- 肥満に関連するインスリン抵抗性の媒介に関与している.
- アディポネクチンの役割を理解することは,代謝疾患の研究にとって極めて重要です.
研究 の 目的:
- アディポネクチンのレベルと2型糖尿病の発症との関連を調査する.
- 2型糖尿病に対するアディポネクチンの予測値を縦断研究で評価する.
主な方法:
- ピマ・インディアン集団の中で,症例対照研究が行われました.
- 2型糖尿病 (症例) を発症した70人の個人を,BMI,年齢,性別に基づいて70人の対照群とマッチングした.
- ベースラインアディポネクチンの濃度を測定し,症例と対照群を比較した.
主要な成果:
- ベースラインアディポネクチン濃度は,後に2型糖尿病を発症した個人では,対照群と比較して有意に低かった (p=0.01).
- ベースラインでのアディポネクチン濃度の上昇は,2型糖尿病の発生率の低下と関連していた (IRR 0.63; p=0.02).
結論:
- アディポネクチンは,2型糖尿病リスクを予測するバイオマーカーとして機能する可能性があります.
- アディポネクチンのレベルが低いと,2型糖尿病を発症する確率が高くなります.
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