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Updated: Jul 5, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

ニフェディピンは,血管の滑らかな筋肉の細胞に依存した経路経由で,内皮細胞におけるスーパーオキシドディスミュータゼ発現を間接的に上調する

Keisuke Fukuo1, Jin Yang, Osamu Yasuda

  • 1Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka, Japan. fukuo@geriat.med.osaka-u.ac.jp

Circulation
|July 18, 2002
PubMed
まとめ

ニフェディピンのようなカルシウム対抗薬は,内皮細胞 (ECs) のスーパーオキシドディスミュータゼ (SOD) を増加させることで内皮機能を改善します. この効果は,血管内皮成長因子 (VEGF) を放出する血管滑らかな筋肉細胞 (VSMC) によって媒介されます.

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Paracrine Signaling

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Pigmentation

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