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スイスにおけるクレウツフェルト・ヤコブ病の発生率
Markus Glatzel1, Colette Rogivue, Azra Ghani
1Institute of Neuropathology and National Reference Center for Prion Diseases, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.
Lancet (London, England)
|July 20, 2002
まとめ
スイスにおけるクレッツフェルト・ヤコブ病 (CJD) の発生率は2001年に倍増し,増加を続けています. 調査では,変異型のCJD症例は見つかりませんでしたが,改善された監視または他の伝播経路による潜在的な増加を示唆しています.
科学分野:
- 神経学 神経学とは
- エピデミオロジー エピデミオロジー
- プリオン病はプリオン病である.
背景:
- スイスにおけるクレッツフェルト・ヤコブ病 (CJD) の発生率は,2001年に大きく2倍に増加した.
- 2002年初頭のデータは,CJD症例の上昇傾向が続いていることを示唆しました.
研究 の 目的:
- スイスにおけるCJDの発生率の増加の背後にある理由を調査する.
- 報告されたCJD症例の特徴を分析し,変異型CJD (vCJD) を排除する.
主な方法:
- 発症時の年齢と疾患の持続時間を含むCJD症例データの分析.
- 病気に関連した変異に対するプリオン遺伝子の遺伝子解析.
- 組織病理学,免疫組織化学,およびGlycotypingは,CJDのサブタイプを区別する.
主要な成果:
- 観察されたCJD発症率の増加は,発症時の年齢や疾患の持続時間の変化と関連していなかった.
- 遺伝子解析では,既知の病気に関連したプリオン遺伝子変異を有する1例のみが特定されました.
- これらの症例のいずれも,変異性CJD (vCJD) の基準を満たしていない.
- 既得CJDの認識されたリスク要因は報告されていません.
結論:
- スイスにおけるCJD事件の増加は,さらなる調査を必要とする.
- 潜在的な説明には,症例報告の改善,イアトロゲン伝播,または動物性プリオン伝播が含まれます.
- これらの症例は,ボウイン・スポンジフォームド・エンセファロパシー (BSE) のプリオン株に起因するものではなかった.
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