妊娠中の亜鉛補給と幼児の精神的発達と行動への影響:フォローアップ研究
Jena D Hamadani1, George J Fuchs, Saskia J M Osendarp
1Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh.
Lancet (London, England)
|July 31, 2002
まとめ
バングラデシュの妊婦の産前亜鉛サプリメントは,乳児の発達を改善しませんでした. プラセボ群の乳児は,13ヶ月でよりよい認知能力と精神運動能力のスコアを示した.
科学分野:
- 母親と子供の健康について
- 栄養科学とは,栄養科学である.
- 発達小児科 発達小児科
背景:
- 亜鉛欠乏症は,開発途上国における重要な公衆衛生問題である.
- 以前の研究では,産前亜鉛サプリメントが乳児の感染症を減少させたことが示されました.
- この研究では,バングラデシュの乳児における産前亜鉛の長期的な発達効果を調査した.
研究 の 目的:
- 13ヶ月の幼児の発達と行動に対する産前亜鉛サプリメントの影響を評価する.
- 妊娠中の母親の亜鉛摂取が子供の発達に及ぼす長期的な影響を評価する.
- 産前亜鉛が,幼児期感染症の軽減以上の効果を与えるかどうかを判断する.
主な方法:
- 亜鉛またはプラセボを割り当てられた559人の妊婦を対象としたランダム化比較試験.
- 168人の乳児のサブサンプルの13ヶ月のフォローアップ評価.
- 幼児発達IIのベイリースケールと行動評価を用いた精神的および精神運動発達の評価.
主要な成果:
- プラセボ群の乳児は,精神的・精神運動的発達指数スコアが著しく高かった.
- 産前亜鉛サプリメントは,幼児の行動や身体的成長に有意な影響を及ぼさなかった.
- 年齢に対する体重で示される栄養状態の悪さ,発達レベルと相関し,治療効果に影響する.
結論:
- バングラデシュの栄養不良の女性の胎児前亜鉛サプリメントだけでは,幼児の精神的発達を向上させません.
- この集団における亜鉛サプリメントの使用は,実証された利益がないため,慎重に検討する必要があります.
- 資源が限られた環境で子どもの発達に最適な栄養介入を探るには,さらなる研究が必要になる可能性があります.
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