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Updated: May 11, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

ペプチドMHCのT細胞受容体認識のための2段階の結合機構

Lawren C Wu1, Delphine S Tuot, Daniel S Lyons

  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, B221 Beckman Center, Stanford, California 94305, USA.

Nature
|August 2, 2002
PubMed
まとめ

T細胞受容体 (TCR) はペプチド-MHC複合体を2段階のプロセスでスキャンします. メジャー・ヒストコンパティビリティ・コンプレックス (MHC) の相互作用が初期ドッキングを誘導し,ペプチド接触が結合を安定させ,T細胞の特異性とクロス反応性を確保する.

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