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関連する概念動画

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...

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Updated: Jun 25, 2026

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

エクトodermal Wntはニューラルクライスト誘導体として機能します.

Martín I García-Castro1, Christophe Marcelle, Marianne Bronner-Fraser

  • 1Division of Biology 139-74, California Institute of Technology, Wilson and California, Pasadena, CA 91125, USA. mig1000@its.caltech.edu

Science (New York, N.Y.)
|August 6, 2002
PubMed
まとめ
この要約は機械生成です。

Wnt信号は,鳥類の胚のニューラル・クライスト細胞発達に不可欠である. これらのWnt分子は,素朴なニューラルプレートからニューラルクライストの形成を誘導するのに十分であり,その重要な役割を強調しています.

キーワード:
非プログラム的なものです.

さらに関連する動画

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
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Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

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関連する実験動画

Last Updated: Jun 25, 2026

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

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11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

科学分野:

  • 発達生物学 発達生物学とは
  • 分子生物学は分子生物学である.
  • 胚学 胚学について

背景:

  • 神経頂部細胞は,外周神経系と顔の骨格の発達に不可欠です.
  • ニューラルクライスト誘導は,ニューラルプレート/外皮の境界で誘導的相互作用を伴う.
  • Wntと骨形態遺伝タンパク質 (BMP) 信号伝達経路は,他の種におけるニューラルクライスト誘導に関与しています.

研究 の 目的:

  • 鳥類の胚におけるニューラルクレスト細胞誘導におけるWnt信号伝達の役割を調査する.
  • ニューラルクレスト細胞を誘発するのにWnt分子が十分かどうかを判断する.
  • 鳥のニューラルクライスト形成におけるWntsとBMPの誘導的能力を比較する.

主な方法:

  • Wnt6 mRNAの局所化は,鳥類のエクトダーマにある.
  • ニューラル・クライスト形成への影響を評価するために,Wnt信号伝達のインビボ抑制.
  • WntsとBMPを使用したネイブニューラルプレートからニューラルクライスト細胞を定義された媒介でインビトロ誘導.

主要な成果:

  • Wnt6は,鳥類の胚のエクトダーマに局所されていることが判明しました.
  • Wntシグナル伝達の阻害は,神経頂部形成を妨げました.
  • Wntsだけでは,追加の要因なしで,ナイブニューラルプレートからのニューラルクレスト細胞をインビトロで誘導することができました.
  • BMPは,神経頂部誘導のための添加物を in vitro で必要とした.

結論:

  • Wnt分子は,鳥類の胚のニューラルクライスト形成に必要である.
  • Wntのシグナリングは,ナイブニューラルプレートからニューラルクレスト細胞を誘導するのに十分です.
  • WNTは,BMPと比較して,鳥のニューラルクライスト誘導において主要な役割を果たします.