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Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
パラジウム触媒によるアルケンおよびアルキンのヒドロフォスフィニル化
Sylvine Deprèle1, Jean-Luc Montchamp
1Department of Chemistry, Box 298860, Texas Christian University, Fort Worth 76129, USA.
Journal of the American Chemical Society
|August 9, 2002
まとめ
パラジウム触媒は,アルケンとアルキンに低酸誘導体を添加することによって,効率的なリンと炭素の結合形成を可能にします. この軽度な方法は,有機リン化合物とH-フォスフィン酸を生成し,改良された合成経路を提供する.
科学分野:
- 有機金属化学 有機金属化学
- カタリシス カタリシス カタリシス
- オーガニック・シンセシス オーガニック・シンセシス
背景:
- パラジウム触媒は,CP結合形成に不可欠である.
- 有機リン化合物の合成のための既存の方法には限界があります.
研究 の 目的:
- 有機リン化合物を合成するための新しい触媒方法の開発.
- ハイポリン酸誘導体のパラジウム触媒の使用を調査する.
主な方法:
- 様々なパラジウム触媒を用いており,その中にはCl(2) Pd (((PPh ((3)) ((2)/2 MeLi,Pd(2) dba ((3) /xantphos. が含まれていた.
- アルケンおよびアルキンと反応した低リン酸派生物 (RO P(O) H(2)).
- 商用用水溶液として使用されているヒポリン酸の水溶液.
主要な成果:
- 温和な条件下でのリン-炭素結合形成の良好な収量を達成しました.
- C-P結合形成に成功し,転送水素化を回避することが実証されています.
- 制御された地域選択性 (線形対分岐型製品) と特定の触媒システム.
- 周りの温度で利用した水性低酸.
結論:
- H-ホスフィン酸と有機リン化合物を調製するための効果的なパラジウム触媒方法を開発した.
- この方法論は,以前の合成経路に比べて,著しく進歩しています.
- 臓器リン酸化学におけるパラジウム触媒の汎用性を強調する.
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