TGF/ARC/

Yoichi Kato1, Raymond Habas, Yu Katsuyama

  • 1Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 9, 2002
PubMed
まとめ

ARC105は,TGFβ/アクティビン/ノダル/Smad2/3のシグナル伝達経路に不可欠であり,それらを遺伝子転写と結びつける. このアクティベーター・リクルート・コファクター (ARC) 複合成分は,Smad依存遺伝子発現を媒介することによって,発育と腫瘍発生を調節する.

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