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Updated: Jul 15, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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サイクルペプチド抗生物質のバイオミメティック合成と最適化

Rahul M Kohli1, Christopher T Walsh, Michael D Burkart

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature
|August 9, 2002
PubMed
まとめ

研究者らは,天然製品の生合成と固体相化学を融合させ,新しい循環ペプチド抗生物質を作成しました. この化学酵素学的アプローチはペプチドを多様化し,抗菌活動と膜選択性の強化された類似体を産生します.

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