典型的な心房の際に,イブチリドに対する右心房の電気生理学的反応
Jie Cheng1, Kathryn Glatter, Yanfei Yang
1Section of Cardiac Electrophysiology, University of California San Francisco, San Francisco, Calif 94143-1354, USA. scheinman@ep4.ucsf.edu
Circulation
|August 15, 2002
まとめ
イブチリドは,心房のサイクル長さを延長し,興奮性を阻害することにより,変動性を増加させます. この効果は,導電ブロックを作り出すことによって,パシングで心房の振動を終了するのに役立ちます.
科学分野:
- 電気生理学 電気生理学
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- イブチリドは,心房細動と動 (AFL) を変換するのに有効です.
- イブチリドが人間の心房に及ぼす電気生理学的効果については,さらなる調査が必要である.
研究 の 目的:
- イブチリドがヒトの心房 flutter に及ぼす電気生理学的効果を調査する.
- イブチリドが心房のサイクル長さと終了にどのように影響するかを理解するために.
主な方法:
- 典型的な心房 (AFL) の12人の患者を研究した.
- 複数の心房部位からの電図を記録した.
- 測定された伝導時間,耐火期,応答曲線のリセット.
- 投与されたイブチリド (15分間に2mg).
主要な成果:
- イブチリドはAFLサイクルの長さを260±30 msから295±39 ms (P<0.0003) に増加させた.
- アトリヤの有効な耐火期は著しく増加した (149±16 ms から 208±26 ms,P<0.001).
- イブチリドは,CLの変動性を増加させ,リセット曲線をシフトさせ,興奮性の喪失を示した.
- イブチリド投与後の8人の患者で,心房オーバードライブのペース付けにより,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で,イブチリド投与後の8人の患者で.
結論:
- イブチリドは,AFL CLを延長し,興奮性のギャップを廃止することにより,変動性を増加させます.
- イブチリドは,機能的な伝導ブロックの開発を通じて,AFLのペース終了を促進する可能性があります.
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