溶解性細胞間粘着分子-1,溶解性血管粘着分子-1,および男性における症状のある外周動脈疾患の発生
Aruna D Pradhan1, Nader Rifai, Paul M Ridker
1Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115-1204, USA.
Circulation
|August 15, 2002
まとめ
溶性細胞間粘着分子-1 (sICAM-1) レベルが上昇すると,健康な男性における周辺動脈疾患 (PAD) の発症が予測されます. この発見は,早期の全身性動脈硬化リスクの潜在的なバイオマーカーとしてsICAM-1を強調しています.
科学分野:
- 心血管医学は,心臓血管医学である.
- バイオマーカー バイオマーカー
- 動脈硬化症の研究研究
背景:
- 溶解性細胞粘着分子は冠動脈事件と関連しています.
- 早期の全身性動脈硬化症との関連は不明である.
研究 の 目的:
- 溶性細胞間粘着分子-1 (sICAM-1) と溶性血管細胞粘着分子-1 (sVCAM-1) のレベルと,症状のある外周動脈疾患 (PAD) の発症との関係を調査する.
主な方法:
- 中年男性14,916人を対象とした展望的,組み合わさった症例対照研究.
- 評価されたベースラインのsICAM-1およびsVCAM-1レベル.
- PADの発達について,9年間参加者を追跡した.
- リスク要因に調整された統計分析.
主要な成果:
- PAD (P=0.005) を発症した男性では,ベースラインより高いsICAM-1レベルが観察されました.
- sICAM-1値の上昇は,調整後にPADリスクの増加 (OR3.5,P=0.008) と著しく関連していました.
- sVCAM-1レベルはPAD発症と関連していなかった.
結論:
- SICAM-1の上昇は,加速性動脈硬化症の独立した予測因子である.
- sICAM-1は,健康な男性におけるPADリスクのバイオマーカーとして機能する可能性があります.
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