Dlx遺伝子によるのサブディビジョンの仕様
Michael J Depew1, Thomas Lufkin, John L R Rubenstein
1Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143-0984, USA.
まとめ
Dlx5およびDlx6遺伝子は,を形成する枝状アーキの近距離軸のパターンを示しています. マウスのDLx5/6の喪失は下を上に変容させ,下の発達におけるその役割を明らかにする.
科学分野:
- 発達生物学 発達生物学とは
- 進化的発達生物学 進化的発達生物学
- 遺伝学 遺伝学とは
背景:
- 脊椎動物のの進化は,枝状の弓の改変と関連している.
- 枝状アーチは,定義された近距離極性を持つ胚構造である.
- Dlx5やDlx6のようなホメオボックス遺伝子は,胚の発達において極めて重要です.
研究 の 目的:
- Dlx5およびDlx6遺伝子が,枝状弧内の骨格要素の同一性を指定する役割について調査する.
- 脊椎動物におけるの形成とパターンの基礎となるメカニズムを理解する.
主な方法:
- Dlx5とDlx6.6の発現が欠けているDlx5/6-/-変異マウスの分析.
- 枝状の弓の発達との形態学への影響の検討.
- 枝状アーチ内のDlx遺伝子の発現パターンを研究する.
主要な成果:
- Dlx5とDlx6が欠けていたマウスは,下下を上下にホメオティックな変容を示した.
- Dlx5とDlx6は,枝状の弧内では,遠端で表されるが,近接的に表されるわけではない.
- ネストDlx遺伝子発現は,枝状弧の近距離軸のパターンを模倣しているようです.
結論:
- Dlx5とDlx6は,枝状弓から派生した骨格要素のアイデンティティを決定する上で重要な役割を果たします.
- ネストドDlx表現は,枝状弧の近距離軸のパターニングに不可欠です.
- Dlx遺伝子発現の修正は,脊椎動物のの進化的発展と精錬に根本的な役割を果たしたのかもしれない.
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