Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Hormonal Regulation01:33

Hormonal Regulation

30.5K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.5K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

3.8K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.8K
Adrenergic Antagonists: ɑ and β-Receptor Blockers01:31

Adrenergic Antagonists: ɑ and β-Receptor Blockers

1.4K
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
1.4K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.9K
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

2.5K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.5K
Veins as Blood Reservoirs01:10

Veins as Blood Reservoirs

7.8K
Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance...
7.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Serum Isolevuglandin IgG Antibody Concentrations Are Increased in Patients with Systemic Lupus Erythematosus and Associated with Lower 24-Hour Blood Pressure.

Frontiers in lupus·2026
Same author

Is anaemia an independent risk factor for postpartum haemorrhage, a marker of increased risk, or both?

International journal of obstetric anesthesia·2026
Same author

ImmuSeeker: deep mining of immune-related gene family signatures through lineage reconstruction.

Genome biology·2026
Same author

A Mendelian randomization-based drug repurposing pipeline: application to lipid traits and coronary artery disease.

medRxiv : the preprint server for health sciences·2026
Same author

Outcomes with intrathecal 2-chloroprocaine 3% 60 mg and fentanyl 15 μg for cervical cerclage: a retrospective quality assurance study (2021 - 2023).

International journal of obstetric anesthesia·2026
Same author

Association of Clonal Hematopoiesis With Incident, Late-Onset, Seropositive Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2026

関連する実験動画

Updated: May 5, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

15.1K

妊娠中の背手静脈におけるアルファ-とβ-アドレナジック感受性の不均衡な減少は,血管拡張を好む.

Ruth Landau1, Victor Dishy, Alastair J J Wood

  • 1Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Circulation
|August 28, 2002
PubMed
まとめ

妊娠は,α1-アドレナジック血管収縮とβ2-アドレナジック血管拡張に対する静脈の感受性を低下させます. この腎上腺反応の変化は,妊娠中に観察される特徴的な血管拡張に寄与する.

さらに関連する動画

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.0K
In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
11:59

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

Published on: April 28, 2023

780

関連する実験動画

Last Updated: May 5, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

15.1K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.0K
In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
11:59

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

Published on: April 28, 2023

780

科学分野:

  • 生理学 生理学とは
  • 薬理学 薬理学とは
  • 産科は産婦人科です.

背景:

  • アドレナージックアゴニストに対する血管の反応の変化は,妊娠中の血圧と胎盤の血流調節に極めて重要です.
  • アルファ1-アドレナジック血管収縮とベータ2-アドレナジック血管拡張は,血管トーンを決定する際に互いに反対します.

研究 の 目的:

  • 妊娠中および妊娠後の背手静脈におけるアルファアドレナジック血管収縮とベータアドレナジック血管拡張を同時に評価する.
  • 妊娠に関連した血管の変化におけるアドレナergic感受性の役割を理解するために.

主な方法:

  • 20人の健康な妊婦 (32-37週間の妊娠期) と出産後の12週間の女性を対象に研究を行った.
  • 線形変数微分変圧器技術を用いて,手の背面静脈におけるフェニルエフリン (PE) とイソプロテレノール (ISO) に対する血管反応の測定.
  • PE誘発の収縮とISO誘発の血管拡張の投与量反応関係が決定されました.

主要な成果:

  • アルファ・アドレナジック感度 (PE CD50) は,妊娠中に7倍低かった (2.7μg/min) が,産後 (0.4μg/min) に比べて (P<0.01).
  • ベータアドレナジック血管拡張は妊娠中に弱まり,ISO ED50 (20 ng/min vs. 8 ng/min) が高く,最大応答が低い (81% vs. 105%) (それぞれP<0.05とP<0.01) でした.

結論:

  • 正常な妊娠は,α1-アドレノ受容体媒介による血管収縮とβ2-アドレノ受容体媒介による血管拡張の両方に静脈の感受性の低下を示します.
  • ベータ2-アドレナジック反応と比較してアルファ1-アドレナジック反応の減少は,ヒト妊娠に典型的な血管拡張状態を説明する可能性がある.