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Updated: Feb 6, 2026

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
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腫瘍発生:RAF/RASオンコゲンと不一致修復状態

Harith Rajagopalan1, Alberto Bardelli, Christoph Lengauer

  • 1Sidney Kimmel Comprehensive Cancer Centre, Howard Hughes Medical Institution and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Nature
|August 29, 2002
PubMed
まとめ

結腸直腸がんにおけるBRAF変異の活性化は,熟練したDNA不一致修復と関連しており,KRAS変異とは独立して発生する. これは,BRAFとKRASが腫瘍発育に類似した役割を果たしていることを示しており,DNA修復を強調しています.

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