代謝ネットワークにおけるモジュラリティの階層的な組織化
E Ravasz1, A L Somera, D A Mongru
1Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA.
Science (New York, N.Y.)
|August 31, 2002
まとめ
細胞組織は機能モジュールに依存しているが,そのネットワーク構造は不明だった. この研究は,代謝ネットワークが階層的なモジュールを形成し,すべての細胞システムに潜在的に共通するパターンであることを明らかにしています.
科学分野:
- システム生物学 システム生物学
- バイオケミストリー バイオケミストリー
- ネットワーク科学 ネットワーク科学
背景:
- 細胞組織は,離散的な機能モジュールを含むと考えられています.
- 複雑な生化学ネットワークにおけるモジュール性の定量的な証拠は限られている.
研究 の 目的:
- 代謝ネットワークのトポロジカルな組織を調査する.
- 代謝ネットワークがモジュラリティと階層構造を示すかどうかを判断する.
主な方法:
- 43種多様な生物の代謝ネットワークの分析.
- トポロジカルモジュールを特定するためにネットワーク理論の適用.
- ネットワークアーキテクチャとEscherichia coli.の既知の代謝機能の比較
主要な成果:
- メタボリックネットワークは,多数の小さな,高度に相互接続されたモジュールに編成されています.
- これらのモジュールは,階層的に統合され,より大きく,より凝固性のない構造を形成します.
- モジュールの分布とクラスタリングは,パワー法則に従う.
- エシェリキア・コリ菌における同定されたモジュラリティは,既知の代謝機能と一致しています.
結論:
- メタボリックネットワークは,階層的なモジュールアーキテクチャを持っています.
- このネットワーク構造は,細胞組織における機能モジュールの定量的なサポートを提供します.
- 観察されたネットワークアーキテクチャは,システムレベルのセルラー組織の一般的な原理を表す可能性があります.
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