超稀少なコードが,歌う鳥のニューラルシーケンス生成の基礎となっている
Richard H R Hahnloser1, Alexay A Kozhevnikov, Michale S Fee
1Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA.
Nature
|September 6, 2002
まとめ
歌う鳥の神経回路は,運動配列を正確にコードする. 特定のHVCニューロンが連続的に活性化し,RAのステレオタイプパターンを駆動し,運動制御のための稀な時間コードを示唆します.
科学分野:
- 神経科学は神経科学である.
- 計算神経科学とは
- 動物の行動 動物の行動
背景:
- モーターシーケンスは,複雑な神経活動パターンによって生成されます.
- 運動前パターンの生成の基礎となる神経機構は不明である.
- 歌う鳥のアーキストリタウム (RA) の頑丈な核は,歌と睡眠の間,ステレオタイプの神経配列を示す.
研究 の 目的:
- 歌う鳥の脳における前運動配列を駆動する神経回路機構を調査する.
- 核HVC (高声中枢) の入力がRAにおける活動をどのように形作るかを理解する.
- 神経配列の生成における時間的なコーディング原理を探求する.
主な方法:
- 眠っている鳥と歌う鳥の特定されたHVCニューロンの電気生理学的記録.
- 曲の制作と睡眠中の神経活動パターンの分析.
- HVCニューロン活動とRAシーケンスの生成の相関.
主要な成果:
- RAに投射する個々のHVCニューロンは,RAシーケンスの内では稀に,正確なタイミングで発火する.
- これらのHVCニューロンは,互いに相対的に連続的な活性化を示します.
- この発見は,異なるHVCサブ集団がシーケンス内の特定の時間点を表すモデルを支持する.
結論:
- HVCニューロンの稀な,連続的な活性化が,RAにおけるステレオタイプの運動配列を駆動する.
- この稀少なコーディングは",祖母細胞"の概念に類似して,時間を明示的に表す可能性があります.
- このようなタイムコードは,シーケンスの学習と生成におけるタイム干渉の問題を軽減することができます.
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