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関連する概念動画

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Reporter Genes02:11

Reporter Genes

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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
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遺伝子の移転によって作られた生物学的ペースメーカー.

Junichiro Miake1, Eduardo Marbán, H Bradley Nuss

  • 1Institute of Molecular Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Nature
|September 13, 2002
PubMed
まとめ

研究者らは,ウイルスの遺伝子転送を使用して,既存の心臓筋細胞から新しいペースメーカー細胞を作成しました. これはリズム的な電気活動を発生させ,心臓病に対する電子ペースメーカーへの潜在的な代替案を提供しました.

科学分野:

  • 心血管生物学 心血管生物学
  • 遺伝子療法の遺伝子治療法
  • 再生医学は,再生医療である.

背景:

  • 心臓のペースメーカー細胞は,心臓のリズムを開始し,調整します.
  • 病気によるこれらの細胞の損傷は,循環器の崩壊につながる可能性があります.
  • 現在の治療には,埋め込み可能な電子ペースメーカーが使われています.

研究 の 目的:

  • 機能的なペースメーカー細胞を生成するためのウイルスの遺伝子転送の可能性を調査する.
  • 心拍の障害の治療のための電子ペースメーカーに代わる代替品を探求する.

主な方法:

  • 静止中の心臓筋細胞を改変するためにウイルスの遺伝子転送を利用した.
  • 生成された電池の電気活動のインビボ評価.

主要な成果:

  • 心筋細胞を機能的なペースメーカー細胞に成功裏に変換した.
  • 室内における自発的,リズム的な電気活動の生成を in vivo で実証した.

結論:

  • 遺伝子組み換えペースメーカーは,電子機器の有望な代替品です.

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  • このアプローチは,心臓リズム管理のための新しい治療戦略を提供することができます.