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Synaptic Signaling01:12

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Neurons: The Axon01:21

Neurons: The Axon

Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.

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関連する実験動画

Updated: May 12, 2026

Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo
10:30

Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo

Published on: January 12, 2014

軸索の誘導信号を翻訳する

Oswald Steward1

  • 1Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine Irvine, CA 92697, USA. osteward@uci.edu

Cell
|September 17, 2002
PubMed
まとめ
この要約は機械生成です。

軸索内のローカルメッセンジャーRNA (mRNA) 翻訳は,成長コンのナビゲーションに不可欠です. このプロセスは,回転反応のためのタンパク質の合成と,誘導信号のための受容体の合成をサポートします.

さらに関連する動画

Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization
11:24

Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization

Published on: June 17, 2015

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
11:56

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila

Published on: June 16, 2017

関連する実験動画

Last Updated: May 12, 2026

Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo
10:30

Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo

Published on: January 12, 2014

Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization
11:24

Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization

Published on: June 17, 2015

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
11:56

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila

Published on: June 16, 2017

科学分野:

  • 神経科学は神経科学である.
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • 軸の誘導は,神経回路の形成に不可欠である.
  • 成長のナビゲーションは,外部のシグナルと内部細胞メカニズムに依存しています.
  • アクソンにおける局所タンパク質合成の役割は,新たな研究分野である.

研究 の 目的:

  • 軸索成長コーンナビゲーションにおけるローカルメッセンジャーRNA (mRNA) 翻訳の重要性を調査する.
  • ガイドラインへの成長コーンの反応における局所タンパク質合成の関与を探求する.
  • 成長が,軸索誘導キューレセプターの局所合成能力を有するかどうかを判断する.

主な方法:

  • 既存の研究と実験的証拠の分析.
  • タンパク質合成に関与する分子および細胞機構のレビュー.
  • 誘導信号に反応する成長の行動の検討.

主要な成果:

  • 証拠によると,軸索内の局所的なmRNA翻訳は,成長コンのナビゲーションに不可欠である.
  • 局所的なタンパク質合成は,成長コンの崩壊を媒介し,誘導シグナルに反応して回転する.
  • 成長は,軸索誘導キュー受容体の局所合成に必要な機構を有しています.

結論:

  • ローカルmRNA翻訳は,成長コーンナビゲーションの重要なメカニズムです.
  • このプロセスは,地元のタンパク質生産を通じて,ガイドラインのシグナルに対するダイナミックな応答を可能にします.
  • 成長は,必要不可欠な誘導受容体の内在的合成に備わっています.