関連する実験動画
Updated: Jun 27, 2026
10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
EGFR/Ebi/Sno経路は,誘導的ノッチシグナル伝達中にSu(H) /SMRTER抑制を無効化することによってデルタ発現を促進します
Leo Tsuda1, Raghavendra Nagaraj, S Lawrence Zipursky
1Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA.
Cell
|September 17, 2002
まとめ
ドロソフィラの目における表皮成長因子受容体 (EGFR) の活性化は,デルタ発現を促進し,細胞の分化に影響を与える配列を開始します. このプロセスには特定のタンパク質が関与し,プロテアソームの活動に依存しています.
科学分野:
- 発達生物学 発達生物学とは
- 細胞シグナリング 細胞シグナリング
背景:
- ノッチと表皮成長因子受容体 (EGFR) 経路は,細胞増殖と分化に不可欠です.
- これらの経路の相互交流は,細胞の反応に大きな影響を与えます.
- その相互作用を理解することは,発達過程の解読の鍵です.
研究 の 目的:
- ドロソフィラの眼の発達におけるEGFRとNotchシグナル伝達を結びつけるメカニズムを解明する.
- EGFRの活性化によって引き起こされる連続的なイベントを特定し,下流シグナリングに影響を与える.
主な方法:
- 発達経路の研究のためのモデル生物としてDrosophila melanogasterを活用しました.
- EGFRとNotchシグナル伝達に関連する遺伝子発現とタンパク質の相互作用を調査した.
- 規制メカニズムを理解するために使用された遺伝的およびプロテアソーム阻害アッセイ.
主要な成果:
- ドロソフィラの眼の発達におけるEGFRの活性化は,光受容体の分化とデルタリンガンドの発現につながる.
- EGFRによって誘発されるデルタは,その後,隣接する細胞に信号を送り,その細胞の状細胞への分化を促進します.
- エビとストロベリーノッチ (sno) のタンパク質は,EGFR依存のデルタ転写に不可欠であり,無毛 (Su(H)) 抑制剤の活性を調節する.
- EGFR媒介の転写性減圧はプロテアソームに依存し,SMRTERの細胞質転位を伴う.
結論:
- 連続したシグナリングカスケードは,ドロソフィラの眼の発達におけるEGFRとNotch経路をリンクします.
- EGFRのシグナリングは,Notch媒介の細胞運命を決定するプロセスを開始します.
- ebi,sno,Su(H) とSMRTERの相互作用は,このEGFRに依存する転写制御の調節に極めて重要です.
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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