血管炎の小児におけるコンタクトシステム活性化
Robin Kahn1, Heiko Herwald, Werner Müller-Esterl
1Department of Paediatrics, Lund University, Lund, Sweden.
Lancet (London, England)
|September 21, 2002
まとめ
血管炎の小児は,ブラジキニンの濃度の上昇によって示される接触システムの活性化を示します. これは,コンタクトシステムが血管炎の病原性および炎症や腫れなどの症状に役割を果たすことを示唆しています.
科学分野:
- 免疫学 免疫学とは
- 病理生理学 病理生理学とは
- 小児科は小児科です.
背景:
- 接触システムは,カルリクレイン-キニンカスケードを開始し,ブラジキニンを放出します.
- コンタクトシステムのコンポーネントは,炎症抑制および血管活性特性を有しています.
- 血管炎は,血管壁の炎症を伴うもので,その分子メカニズムは十分に理解されていない.
研究 の 目的:
- 小児血管炎患者における接触システム活性化を調査する.
- 接触システム活性化と血管炎症状の関連性を調べる.
主な方法:
- 血管炎を患った17人の子どもと,健康な対照群21人を比較した.
- 免疫ボルトリングによる高分子量キニノゲンタンパク質分解を分析した.
- ELISAを用いた血ブラジキニンとヘパリン結合タンパク質 (HBP) の定量化;キニンの染色生検.
主要な成果:
- 広範な高分子量キニノゲンタンパク質分解は,1/21対照群 (p<0.0001) と対比して13/17人の患者で観察されました.
- 患者におけるブラジキニンの血濃度 (中位320ng/L) と対照群 (11ng/L) (p=0.0004) の著しく高かった.
- 患者 (17.4μg/L) と対照群 (6μg/L) のHBP濃度の上昇 (p=0.008);炎症組織における局所キニンの放出.
結論:
- 接触システムの活性化は,血管炎の病原性に関与しています.
- この活性化は,血管炎患者における炎症,痛み,血管拡張,および腫を説明する可能性がある.
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