刺激性腸症候群:ほとんど理解されていない有機腸疾患?
Nicholas J Talley1, Robin Spiller
1Department of Medicine, University of Sydney, NSW, Australia. ntalley@med.usyd.edu
Lancet (London, England)
|September 21, 2002
まとめ
刺激性腸症候群 (IBS) は,成人の10%に影響を与え,生活の質を低下させます. 治療は満足のいくものではありませんが,認知行動療法や低用量トリサイクル抗うつ剤などの治療は,IBSの症状を管理する有望なことを示しています.
科学分野:
- 胃腸内科 胃腸内科
- 神経胃腸内科 神経胃腸内科
- 精神科医は精神病を患っている.
背景:
- 刺激性腸症候群 (IBS) は,成人の10%,主に女性に影響を与え,生活の質を低下させ,医療費を大幅に削減します.
- 家族のクラスタリングは,遺伝的傾向と家族内学習の両方の役割を示唆しています.
- 主な特徴は,内臓過敏症と,アファレント信号解釈における潜在的な中央処理障害を含む.
研究 の 目的:
- 刺激性腸症候群 (IBS) の病理生理学,診断,治療に関する現在の理解をレビューする.
- IBSが患者の生活の質や医療システムに与える影響を強調する.
- IBSに対する様々な治療介入の有効性を調査する.
主な方法:
- IBSの病理生理学,遺伝学,環境要因に関する研究の文献レビュー.
- 症状と警報指標の欠如に基づく診断基準の分析.
- 薬理学的および非薬理学的介入における治療結果の評価.
主要な成果:
- IBSは,内臓過敏症と感覚信号の中央処理の変化によって特徴付けられます.
- 感染症,炎症,慢性ストレスなどの環境要因が影響する.
- 低用量のトリサイクル抗うつ剤と認知行動療法では,長期的な利益の可能性が示されています.
結論:
- 現在のIBS治療法は依然として不満足であり,改善された治療戦略の必要性を強調しています.
- 強い医師と患者の関係は,IBSの症状悪化の管理に不可欠です.
- IBSにおける遺伝子と環境要因の複雑な相互作用を明らかにするために,さらなる研究が必要である.
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