発話に関連する脳の領域の断絶は,持続的な発育性うなずきにおいて起こります
Martin Sommer1, Martin A Koch, Walter Paulus
1NeuroImage Nord, Department of Neurology, University of Hamburg, Hamburg, Germany.
Lancet (London, England)
|September 21, 2002
まとめ
持続的な発育性うなずきは,脳の白質経路の障害に起因し,言語生産に影響を与える可能性があります. この研究は,脳半球の優位性の問題だけでなく,神経伝達障害が発の根底にあることを示唆しています.
科学分野:
- 神経科学は神経科学である.
- 神経学 神経学とは
- スピーチサイエンス スピーチサイエンス
背景:
- 持続的な発育不全の根本的な原因は不明である.
- 仮説には,左半球の優位性が低下し,右半球の過剰活性化,または左半球内の主要な赤字につながる.
- 以前の研究では,左半球の言語領域のタイミング障害が示唆され,おそらく白質の障害による神経伝達障害を示唆しています.
研究 の 目的:
- 言語に関連する皮質領域間の構造的な断絶が持続的な発育不全の基礎であるかどうかを調査する.
- 吃音する人の特定の脳の構造的な違いを特定するために.
主な方法:
- 発育不全が持続した15人の個体と,不全の重症度を定量化するためにマッチした15人の対照群のスピーチ分析.
- 拡散テンサー画像 (DTI) は,脳組織の微細構造を検査するために使用されました.
- 2つのサンプルのtテストを使用して, stammeringとコントロールグループ間の拡散特性を比較しました.
主要な成果:
- 発グループと対照群の間で,拡散特性の有意な差異が観察されました.
- これらの差異は,左側感覚運動皮質の喉頭と舌の表現領域のすぐ下に局所化した.
- 分数アニソトロピーの平均差は0.04 (95%CI 0.03-0.05) であった.
結論:
- 持続的な発育性うなずきは,言語に関係する脳の領域の活性化のタイミングの障害と関連しています.
- この発見は,右半球の過剰活性化が,アファシアで観察されるパターンに似た補償反応である可能性があることを示唆している.
- 言語に関連する経路における構造的な断絶は,口吃の重要な要因として関与しています.
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