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Updated: Jul 9, 2026

New Variations for Strategy Set-shifting in the Rat
09:45

New Variations for Strategy Set-shifting in the Rat

Published on: January 23, 2017

動物実験のシステマティック・レビュー

Peter Sandercock1, Ian Roberts

  • 1Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK. pags@skull.dcn.ed.ac.uk

Lancet (London, England)
|September 21, 2002
PubMed
まとめ

No abstract available in PubMed .

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Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...