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オーストラリアの女性におけるプロヒビチン3'未翻訳領域ポリモルフィズムと乳がんリスク
Amanda B Spurdle1, John L Hopper, Xiaoqing Chen
1Cancer and Cell Biology Division, Joint Experimental Oncology Programme, Queensland Institute of Medical Research, and University of Queensland, Brisbane, Australia. mandyS@qimr.edu.au
Lancet (London, England)
|October 2, 2002
まとめ
北米の女性における乳がんに関連したプロビビチン遺伝子ポリモルフィズムは,オーストラリアの女性における乳がんリスクの増加と関連していなかった. この発見は,この特定の遺伝的変異が乳がんの発症に寄与するという仮説を支持しません.
科学分野:
- 遺伝学 遺伝学とは
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- プロビチン遺伝子の3'未翻訳領域のCからTへの移行は,mRNAの機能に影響する.
- 以前の研究では,Tアレルと,家族歴のある50歳未満の北米女性における乳がんリスクの増加との関連が示唆されていた.
研究 の 目的:
- プロビビチン遺伝子ポリモルフィズム (C から T への移行) とオーストラリアの女性の乳がんリスクとの関連を調べる.
- 以前に報告された関連が,別の集団に一般化できるかどうかを判断する.
主な方法:
- 集団ベースのケース・コントロール研究が行われました.
- 1446件の症例と786件の対照群を分析した.
- 統計分析には,オッズ比率と信頼区間が含まれ,年齢と家族歴によるサブグループ分析が行われました.
主要な成果:
- プロビビチン遺伝子Tアレルとオーストラリアの女性の乳がんリスクとの間に有意な関連性が見つかりませんでした (OR 0.96,95%CI 0.80-1.16; p=0.7).
- 年齢,家族歴,またはその両方によるサブグループ分析も,有意な関連性を明らかにしなかった.
- 結果は,研究されたオーストラリア人集団における仮説に対する支持の欠如を示しています.
結論:
- プロビティチン遺伝子ポリモルフィズムが,オーストラリアの女性における乳がんリスクに寄与しているようには見えません.
- この発見は,以前に報告された関連が集団特異的か,または他の要因の影響を受ける可能性があることを示唆しています.
- 異なる集団における乳がんの病因における遺伝的ポリモルフィズムが果たす役割を完全に理解するためには,さらなる研究が必要である.
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