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人間におけるダイナミック・ serebral autoregulationの自律神経制御
Rong Zhang1, Julie H Zuckerman, Kenichi Iwasaki
1Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and the University of Texas Southwestern Medical Center at Dallas, Tex 75231, USA.
Circulation
|October 3, 2002
まとめ
自律神経制御は,ダイナミックな脳の自己調節に大きく影響する. ギャングリオン阻害は脳血流の調節を変化させ,拍子対拍子制御にトニック・オートノミック・アクティビティが不可欠であることを示唆している.
科学分野:
- 生理学 生理学とは
- 神経科学は神経科学である.
- 心血管研究 循環器科の研究
背景:
- 自律神経制御は,安定した生理学的機能を維持するために不可欠です.
- ダイナミック・セレブラル・オートレギュレーションは,血圧の変動中に脳機能を保護します.
研究 の 目的:
- ダイナミックな脳の自己調節における自律神経制御の役割を調査する.
- 自律的封鎖が脳の血流調節にどのように影響するかを評価する.
主な方法:
- 12人の健康な被験者にトリメタファンでギャングリオンブロックを施した.
- 血圧と中脳動脈の血流速度を測定した.
- 移転機能分析は,動的脳自己調節を定量化しました.
主要な成果:
- ギャングリオンブロックは,血圧と脳血流の速度を低下させた.
- 自律的封鎖により,移転機能の獲得が増加し,相リードが低下し,動的脳自律調節が損なわれていることを示しています.
- これらの変化は,血圧が正常化した後でさえも続いた.
結論:
- ダイナミックな脳の自己調節は,自律的ブロックによって著しく変化します.
- 脳循環の自律神経制御は,トニカルアクティブである.
- 自律的制御は,脳血流のビート・トゥ・ビートの調節に重要な役割を果たします.
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