関連する実験動画
Updated: Jul 10, 2026
08:13
Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart
Published on: September 13, 2011
動脈動の間に動脈動の可能性の代替は,動脈動の前駆体として動脈動の前駆体です
Sanjiv M Narayan1, Frank Bode, Pamela L Karasik
1University of California and Veterans Affairs Medical Center, San Diego, Calif, USA.
Circulation
|October 9, 2002
まとめ
アトリアルフラッターは,静脈の交差点でのアクションポテンシャルの交替を経由して,動に転移する. 速度の適応不良と伝導阻害によって特徴づけられるこの電気的不安定は,心房細動を誘発し,静脈断絶を正当化することがあります.
科学分野:
- 電気生理学 電気生理学
- 心律不整症とは,心律不整症のこと.
背景:
- 典型的な動 (Afl) から動 (AF) に移行するメカニズムは完全に理解されていません.
- この研究では,AflからAFへの変換におけるアクションポテンシャルアルターナンの役割を調査しました.
研究 の 目的:
- 動脈が動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動
- AflからAFへの移行の基礎となる電気生理学的メカニズムを特定する.
主な方法:
- モノフェーシック・アクション・ポテンシャル (MAP) は,オーバードライブ・ペースの際に,右心房間と右心房の他の部位から記録された.
- ペースは,AFの開始または160 msのサイクル長さに達するまで継続しました.
- MAPの持続時間と振幅の変数,および伝導ブロックはAF発症との関係で分析されました.
主要な成果:
- AFを発症した患者は,AF発症に先立つ地峡でMAPの持続時間と振幅の交替を示しました.
- 速度誘発のMAPの持続変位と2:1の導電ブロックは,AFに移行する患者で観察されました.
- MAPの代替薬は,AFを発症しなかった患者では,より頻繁に,より速いペースで発生しました.
結論:
- 右心房静脈におけるアクションポテンシャルの持続時間率の適応不良は,アルターナンと伝導ブロックを沈殿させ,AFへの移行を促進する可能性があります.
- これらの静脈の電気生理学的特性は,波長の分断を介してAFの開始を可能にします.
- 発見は,AFをAFに変換する際の島の役割を支持し,AF再発を防止する際の島除去の有効性を説明する可能性がある.
関連する概念動画
01:13The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
01:07Overview of the Heart
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
01:16Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
01:16Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
01:29Cardiac Cycle
The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
01:18Physiology of the Heart: The Cardiac Cycle
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...