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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Drug Distribution: Tissue Binding

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Updated: Jul 9, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

ロスマンとシェクマンは人身売買でラスカーに逮捕された.

Vivek Malhotra¹, Scott D Emr

¹Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA. malhotra@biomail.ucsd.edu

|October 10, 2002

まとめ

ジェームズ・ロスマンとランディ・シェクマンは,膜交通メカニズムに関する画期的な研究でラスカー賞を受賞した. 彼らの研究は,細胞が不可欠な分子をどのように運ぶのかについての私たちの理解を大幅に前進させました.

科学分野:

細胞生物学細胞生物学
分子生物学は分子生物学である.
バイオケミストリーバイオケミストリー

背景:

細胞のプロセスは,膜に結合したコンパートメント内の分子の正確な輸送に依存しています.
機能不全の膜交通は,神経学的障害や代謝状態を含む多数の疾患に起因しています.

研究の目的:

ジェームズ・ロスマンとランディ・シェクマンが膜トラフィックを理解する上で果たした重要な貢献を称える.
膀の輸送と融合を制御する分子機構を解明する.

主な方法:

この研究には,酵母における遺伝分析と,哺乳類の細胞における膀輸送の生化学的再構成が含まれていた.
膀の芽生え,ターゲティング,融合を調節する主要なタンパク質と経路が特定されました.

主要な成果:

ロスマンとシェクマンは,膀媒介による輸送の分子主体と規制原理を特定した.
彼らの研究は,膀が標的膜と接着し融合し,細胞の荷物を正確に送達することを保証する方法を明らかにしました.

結論:

ロスマンとシェクマンの発見は,セルラー・ロジスティックの基本的枠組みを提供する.

さらに関連する動画

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Published on: April 18, 2018

Shotgun Lipidomics of Rodent Tissues

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

関連する実験動画

Last Updated: Jul 9, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Published on: April 18, 2018

Shotgun Lipidomics of Rodent Tissues

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

この研究は,健康と病気の理解に深い意味を持ち,治療的介入の道を開きます.