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関連する概念動画

Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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関連する実験動画

Updated: May 10, 2026

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
13:36

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT

Published on: October 1, 2010

ソマティック細胞の核移転

I Wilmut1, N Beaujean, P A de Sousa

  • 1Roslin Institute, Roslin, Midlothian EH25 9PS, UK. ian.wilmut@bbsrc.ac.uk

Nature
|October 11, 2002
PubMed
まとめ
この要約は機械生成です。

大人の体細胞からの核移植クローニングは,顕著な発達可塑性を示しています. このプロセスは細胞の分化を逆転させ,細胞核が発育を期間に至るまで導くことができる.

さらに関連する動画

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning
04:36

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

関連する実験動画

Last Updated: May 10, 2026

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
13:36

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT

Published on: October 1, 2010

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning
04:36

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

科学分野:

  • 発達生物学 発達生物学とは
  • 細胞を再プログラムする.
  • 繁殖技術は,生殖技術である.

背景:

  • ソマティック細胞核移転 (SCNT) は,クローン子孫を生み出すための技術です.
  • 大人の体細胞は,通常,微分化されたクロマチンの構造を持っています.
  • 卵細胞の細胞質には,微分した核を再プログラムできる要素があります.

研究 の 目的:

  • 成体体体細胞の核の発達の可塑性を実証する.
  • 差別化を制御するエピジェネティック変異を逆転させる可能性を調査する.
  • 再プログラムされた核が長期的に完全な開発をサポートする能力を確認する.

主な方法:

  • ソマティック細胞の核をエヌクレア化卵細胞に核移転する.
  • 復元された胚の培養はin vitro.
  • 生存可能な胚の移植は,妊娠のための代理母にします.

主要な成果:

  • 核移植後のクローン胚の育児に成功した.
  • 体細胞の分化マーカーの逆転の証拠.
  • 卵細胞の再プログラム能力の実証.

結論:

  • 大人の体細胞からの核移転によるクローニングは実現可能である.
  • オオサイト・サイトプラズマは,微分化された体細胞核を再プログラムすることができます.
  • 発達の可塑性は,核再プログラミングの重要な特徴である.