ニューロトロフィンによって誘発される脱極化は,ナトリウムチャネルNa(V) 1.9を必要とします
Robert Blum1, Karl W Kafitz, Arthur Konnerth
1Institut für Physiologie, Ludwig-Maximilians-Universität München, D-80336 München, Germany.
Nature
|October 18, 2002
まとめ
脳由来神経栄養素因子 (BDNF) は,Na(V) 1.9ナトリウムチャネル経由でニューロンを刺激する. この発見は,ニューロトロフィンがナトリウムチャネルを活性化し,脳の機能とシナプス可塑性に影響を与えるための新しいメカニズムを明らかにしています.
科学分野:
- 神経科学は神経科学である.
- 分子生物学は分子生物学である.
- セルラー・シグナリング
背景:
- 脳由来ニューロトロフィック因子 (BDNF) を含むニューロトロフィンは,脳の機能に不可欠です.
- BDNFとニューロトロフィン-4/5は,中枢神経系のニューロンを刺激し,シナプス可塑性に影響を与えます.
研究 の 目的:
- ニューロトロフィンによって引き起こされるニューロン刺激の基礎となる分子メカニズムを解明する.
- ニューロトロフィンの伝送器のような作用に起因する特定のイオンチャネルを特定する.
主な方法:
- アンチセンセスのメッセンジャーRNA発現を用いた候補遺伝子のスクリーニング.
- TrkB受容体チロシンキナーゼを様々なナトリウムチャネルで共発する.
主要な成果:
- テトロドトキシン無感性ナトリウムチャネルNa(V) 1.9をニューロトロフィンが誘発する興奮の主要な媒介物として特定した.
- Na(V) 1.9がニューロトロフィン誘発のニューロンの脱極化の原因であることを示した.
結論:
- ニューロトロフィンが誘発する脱極化の分子基盤を確立した.
- ニューロトロフィンによるリガンド媒介ナトリウムチャネル活性化の新しいメカニズムを明らかにした.
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At rest, the K+ is the main ion that moves across the membrane through...
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