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Updated: Jul 18, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

PrPがサイトゾールに蓄積すると神経毒性と神経変性が生じます

Jiyan Ma1, Robert Wollmann, Susan Lindquist

  • 1Howard Hughes Medical Institute, Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

Science (New York, N.Y.)
|October 19, 2002
PubMed
まとめ

サイトゾールに蓄積する誤ったプリオンタンパク質 (PrP) は高度な神経毒性であり,マウスのアタキシアと小脳変性を引き起こす. この細胞性PrP種は,自己増殖PrP (Sc) イソフォームとは異なる.

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