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MMPsの構造ベースの薬物設計に対する移動性の影響

Franklin J Moy1, Pranab K Chanda, James Chen

  • 1Department of Biological Chemistry Wyeth Research, 87 Cambridge Park Dr., Massachusetts 02140, USA.

Journal of the American Chemical Society
|October 24, 2002
PubMed
まとめ

薬剤の設計では,タンパク質のダイナミクスを無視することが多い. マトリックス金属タンパク質酵素 (MMPs) の場合,活性部位の移動性は,化合物1がMMP-1に高親和性で意外と結合する理由を説明し,静的構造の予測に挑戦しています.

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