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Updated: Jul 21, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
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Published on: June 21, 2018

ニコチンのアセチルコリン受容体の結合部位におけるpKの混乱:ニコチンの結合への影響

E James Petersson1, Anita Choi, David S Dahan

  • 1Division of Chemistry and Chemical Engineering, Division of Biology, California Institute of Technology, Pasadena 91125, USA.

Journal of the American Chemical Society
|October 24, 2002
PubMed
まとめ

研究者は,結合アゴニストを使用して自己ゲートニコチンアセチルコリン受容体 (nAChRs) を作成しました. これらの改変された受容体は,pHに依存する活性を示し,pHが低い場合,受容体は反転的に活性化され,薬理学研究に影響を与えます.

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