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Updated: Jul 17, 2026

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D(2) OとH(2) Oにおける飽和移転差 NMR実験で,小さなRNA標的へのリガンド結合を検出する

Moriz Mayer1, Thomas L James

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.

Journal of the American Chemical Society
|November 7, 2002
PubMed
まとめ

飽和伝達差 (STD) NMRは,小さなRNAモチーフを使用してRNA-リガンドの相互作用を効果的にスクリーニングします. オキシドデウテリウム (D2O) 溶媒は,リラックス率を低下させ,薬剤発見のためのスクリーニング効率を改善することによって検出を強化します.

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