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Updated: Jul 23, 2026

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NO誘発によるヘム調節されたeIF2αキナーゼの活性化メカニズム

Haruto Ishikawa1, Bo-Geon Yun, Satoshi Takahashi

  • 1Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.

Journal of the American Chemical Society
|November 15, 2002
PubMed
まとめ

酸化窒素 (NO) は,ヘム鉄と結合することで,ヘム調節されたエウカリオット初期因子2alpha (eIF2alpha) キナーゼ (HRI) を活性化します. この活性化メカニズムは,鉄-ヒスティジル結合の破壊ではなく,特定のNO-アミノ酸相互作用を伴う.

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