コーヒーの消費と2型糖尿病のリスク
Rob M van Dam1, Edith J M Feskens
1Department of Chronic Diseases Epidemiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands. robvdam@bio.vu.nl
Lancet (London, England)
|November 16, 2002
まとめ
毎日少なくとも7杯のコーヒーを飲むと,2型糖尿病を発症するリスクが著しく低下します. この研究は,コーヒーを強調しています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 栄養学的流行病学について
- メタボリック疾患
背景:
- コーヒーは,インスリン感受性に対する急性効果で知られているカフェインの主要な源です.
- インスリン感受性に対するカフェインの影響は複雑であるが,コーヒーの消費は保護的な効果をもたらす可能性がある.
- 2型糖尿病は,多因性の病因性を持つ世界的な健康問題である.
研究 の 目的:
- コーヒー消費と臨床型2型糖尿病の発生率との関係を将来的に検討する.
- コーヒーの摂取量の増加が2型糖尿病の発症リスクの低下と関連しているかどうかを調査する.
- この関連性を,人口ベースの大規模なコホートで評価する.
主な方法:
- 展望的なコホート研究デザインで,30歳から60歳のオランダ人男性と女性1万7千111人を対象とした.
- 125,774人年という相当なフォローアップ期間におけるデータ収集.
- コーヒーの摂取と2型糖尿病のリスクとの関連を判断するために,潜在的な混同要因に調整された統計分析.
主要な成果:
- フォローアップ期間中に新たに306例の2型糖尿病が診断されました.
- 毎日7杯以上のコーヒーを飲む人は,2杯以下を飲む人と比較して,2型糖尿病を発症する可能性が50%低いことが示されました.
- 高コーヒー消費と2型糖尿病のリスクとの間には,統計的に有意な逆関連 (p=0.0002) が観察されました.
結論:
- コーヒーの消費は,2型糖尿病を発症するリスクを大幅に低下させる.
- コーヒーを毎日多く摂取することは,2型糖尿病に対する保護因子であるようです.
- これらの発見は,糖尿病予防戦略におけるコーヒーの潜在的な役割を示唆しています.
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