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関連する概念動画

Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Convergent Evolution01:54

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.

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関連する実験動画

Updated: May 9, 2026

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras
09:38

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras

Published on: May 31, 2014

羽毛の形態発生について

Mingke Yu1, Ping Wu, Randall B Widelitz

  • 1Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90033, USA.

Nature
|November 21, 2002
PubMed
まとめ

羽根の分岐は,ノギンと骨の形態遺伝タンパク質4 (BMP4) の間の分子バランスに依存し,ソニック・ヘッジホッグ (Shh) がバーブ間隔を制御します. これは,羽毛の進化の重要な発達経路を明らかにしています.

科学分野:

  • 発達生物学 発達生物学とは
  • 進化生物学の進化生物学について
  • パレオントロジー・パレオントロジー

背景:

  • 羽は,鳥の飛行に不可欠な複雑で枝分かれした構造です.
  • 恐竜の"羽毛のような"構造の化石発見は,羽根の起源と進化に関する疑問を投げかけている.
  • 真の羽根と原羽根を区別することは,依然として困難です.

研究 の 目的:

  • 羽根の枝分かれ形態変異を駆動する分子機構を調査する.
  • 羽根構造の進化に関与する発達経路を理解する.

主な方法:

  • 複製能力の有能な鳥肉腫レトロウイルスを使用して,鶏の羽毛の卵泡を再生する遺伝子配送を行いました.
  • 羽毛の発達における特定のシグナル伝達経路 (ノギン,BMP4,Shh) の役割を分析した.

主要な成果:

  • 羽根と骨の形態遺伝タンパク質4 (BMP4) のバランスが羽根の分岐に決定的に重要であることを示した.
  • BMP4はラキス形成とバーブ融合を促進し,ノギンは枝分かれを促進します.
  • ソニック・ヘッジホッグ (Shh) はアポトーシスを誘発し,バーブ間の空間を作り出す.

結論:

さらに関連する動画

Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

Using Avian Skin Explants to Study Tissue Patterning and Organogenesis
09:30

Using Avian Skin Explants to Study Tissue Patterning and Organogenesis

Published on: September 15, 2023

関連する実験動画

Last Updated: May 9, 2026

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras
09:38

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras

Published on: May 31, 2014

Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

Using Avian Skin Explants to Study Tissue Patterning and Organogenesis
09:30

Using Avian Skin Explants to Study Tissue Patterning and Organogenesis

Published on: September 15, 2023

  • 標識された分子経路 (ノギン,BMP4,Shh) は,円筒状の表皮を枝分かれした羽根構造に変換するのに不可欠です.
  • 多様な羽の形態の進化の基礎となる発達メカニズムについての洞察を提供した.