妊娠中の発熱と胎児死亡のリスク:コホート研究
Anne-Marie Nybo Andersen1, Pernille Vastrup, Jan Wohlfahrt
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark. a.nybo@socmed.ku.dk
Lancet (London, England)
|November 22, 2002
まとめ
妊娠初期における発熱は胎児死亡のリスクを増加させない. この大規模なデンマークの研究では,発熱の強度や発熱のタイミングが異なる場合でも,母体発熱と流産や死産との間には関連性がないことが判明しました.
科学分野:
- 生殖器保健は,生殖器の健康についてです.
- 産科は産婦人科です.
- テラトロジー・テラトロジーとは
背景:
- 熱中症は動物において知られているテロゲンであり,潜在的に胎児の再吸収と死亡を引き起こす可能性があります.
- 妊娠中の発熱,特に胚形成期における発熱は胎児死亡の危険因子として疑われています.
研究 の 目的:
- 妊娠初期における母体熱と胎児死亡のリスクとの関連を調査する.
- 妊娠16週間の発熱が妊娠の結果に影響するかどうかを判断する.
主な方法:
- デンマーク国立出生コホート研究における24,040人の妊婦を対象とした大規模なコホート研究.
- 妊娠16週間の発熱 (温度,期間,タイミング) に関するインタビューで収集されたデータ.
- 妊娠の結果は,国家登録簿とのリンクを通じて特定され,コックス回帰を用いて分析された.
主要な成果:
- 18.5%の女性が最初の16週間に少なくとも1回の発熱を報告しました.
- 母親の発熱と胎児死亡との間に統計的に有意な関連性が見つかりませんでした (RR 0.95; 95% CI 0.80-1.13).
- この関連性の欠如は,異なる発熱の特徴と妊娠年齢,およびすべての trimester で胎児死亡に対して一貫したままでした.
結論:
- 妊娠16週間の発熱が胎児死亡のリスクを高めるという証拠はありません.
- 研究結果は,臨床的に認められた妊娠は,妊娠初期発熱による胎児死亡のリスクが高くないことを示しています.
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