アプリジンHCl.でオアバイン誘発の心室リズムを抑制する. 他の抗不律性薬との比較
Circulation
|February 1, 1976
まとめ
加速心室脱出 (AVE) と重複心室応答 (RVR) は,ほとんどの抗不律薬で抑制することが困難です. アプリンジンだけが,犬におけるこれらの心律不良を抑制するのに100%の成功を示した.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
- 獣医医学 獣医医学は,獣医医学というものです.
背景:
- オアバインの投与は,犬の加速性心室脱出 (AVE) と重複性心室応答 (RVR) のような不律を誘発する可能性があります.
- これらの心律乱は,コントロール被験者の安定した脱出間隔によって特徴付けられています.
- RVRとAVEのイオン基は,遅い電流が関与しているかもしれないが,ほとんど不明のままである.
研究 の 目的:
- 犬のモデルでオアバイン誘発のAVEとRVRを抑制する様々な抗リズム剤の有効性を評価する.
- これらの心房不律症の管理における特定のイオンと薬物クラスの役割を調査する.
主な方法:
- 3組の犬にオアバインを投与し,AVEとRVRを誘導した.
- 様々な抗リズム薬 (キニジン,リドカイン,プロカイナミド,プロプラノロール,ベラパミル,アプリンジン) と介入薬 (KCl,カルシウム塩化物) が抑止作用について試験された.
- 制御犬は安定した脱出間隔をモニターした.
主要な成果:
- テストされた抗リズム剤のほとんどは,AVEとRVRを抑制することに限られた成功率 (0~33%) を示した.
- カリウムカンレノアートは効果がなく,ボラスベラパミルは部分抑制 (21-41%) を示した.
- 連続ベラパミル注入とKCl注入 (血清カリウムを7.2mEq/Lに上昇させる) が有効でした.
- アプリンジン (2.86 mg/kg) は,すべての犬においてAVEおよびRVRの100%抑制を達成しました.
- カルシウム塩化物は,アプリジンとベラパミルによって誘発された抑制を逆転させた.
結論:
- オアバイン誘発のAVEとRVRは,一般的に,一般的に使用される抗不律薬による抑制に耐性がある.
- アプリンジンは,この犬のモデルで完全な有効性を実証した唯一の薬剤でした.
- これらの発見は,これらの心律乱症の病原性における遅い電流の潜在的な役割を示唆し,アプリンジンを有望な治療法として強調しています.
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