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高血圧および腎血管疾患の患者における酸化ストレスおよび血小板活性化の増加
Pietro Minuz1, Paola Patrignani, Stefania Gaino
1Department of Biomedical and Surgical Sciences, University of Verona, Italy. pietro.minuz@mail.univr.it
Circulation
|November 27, 2002
まとめ
腎血管疾患の高血圧患者は,レニン-アニオテンシンシステムの活性化に関連した酸化ストレスと脂質過酸化の上昇を示します. 血管新生整形はこれらのマーカーを減少させることができ,病気の進行における酸化ストレスが役割を果たすことを示唆しています.
科学分野:
- 心血管研究 循環器科の研究
- ネフロロジーは腎臓科
- オキシダティブ・ストレスは,
背景:
- 腎血管疾患 (RVD) の高血圧患者は,酸化ストレスが増加することがあります.
- レニン-アニオテンシンシステムの活性化は,このストレスに潜在的に寄与する要因である.
研究 の 目的:
- RVD患者における脂質過酸化と血小板活性化のマーカーを,本質的な高血圧と健康な対照群と比較して調査する.
- これらのマーカーとレニン=アニオテンシン系との関係を調査する.
- これらのマーカーに対する血管形成術の影響を評価する.
主な方法:
- 脂質過酸化と血小板活性化の指標として,尿中の8-イソプロスタグランジンF2αと11-デヒドロトロンボキサンB2を測定した.
- 評価されたプラズマレニン活性,アンジオテンシンII,脂質,グルコース,ホモシステイン,抗酸化ビタミン.
- 腎動脈血管新生手術前と手術後の6ヶ月間,患者を研究した.
主要な成果:
- 尿中の8 - アイソプロスタグランジンF2アルファは,本質的な高血圧または健康な被験者よりも,RVD患者で有意に高かった.
- 尿中の11-デヒドロトロンボキサンB2も,対照群と比較して,RVD患者で上昇した.
- RVD患者では,8-iso-PGF2alphaは血小板活性化とレニン-アニオテンシンシステムの活性と相関し,血管新生手術により,一部の患者では8-iso-PGF2alphaが減少した.
結論:
- リピド過酸化は,RVDの高血圧患者で有意に増加し,レニン-アンジオテンシンシステムの活性化に関連しています.
- 持続的な血小板活性化は,イソプロスタンによって潜在的に増幅され,RVDにおいて心血管および腎臓の損傷を誘導する可能性があります.
- これらの発見は,RVDの病原性における酸化ストレスが果たす役割を強調しています.
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