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Updated: Aug 13, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

LDL受容体の細胞外ドメインの構造は,エンドソームのpHで

Gabby Rudenko1, Lisa Henry, Keith Henderson

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Y4-206, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|December 3, 2002
PubMed
まとめ

低密度リポタンパク質受容体は,エンドソーム内のコレステロールを放出します. 提案されたメカニズムは,ベータプロペラドメインが代替基板として作用し,コレステロールホメオスタシスのためのカルシウム依存性リポタンパク質の放出を促進することを含む.

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Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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The Early Endosome: Endocytosis of Transferrin

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Receptor Downregulation in MVBs

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Clathrin Coated Vesicles

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Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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