肥満とインスリン抵抗性の違い,C反応性タンパク質との関連
Tracey McLaughlin1, Fahim Abbasi, Cindy Lamendola
1Stanford University School of Medicine, Stanford, Calif, USA.
Circulation
|December 4, 2002
まとめ
C反応性タンパク質 (CRP) の上昇は,肥満だけでなく,インスリン抵抗性に関連しています. 体重減少はインスリン抵抗性を改善し,肥満者のCRPレベルを下げる.
科学分野:
- エンドクリノロジー エンドクリノロジー
- メタボリックシンドロームとは
- 炎症マーカー 炎症マーカー
背景:
- 血のC反応性タンパク質 (CRP) は,肥満および高インスリン血症の個体において上昇しています.
- 肥満とインスリン抵抗性は,CRPレベルの増加と関連しています.
研究 の 目的:
- インスリン抵抗性とCRPの関係が肥満とは無関係であるかどうかを調査する.
- 体重減少がCRPとインスリン抵抗性に与える影響を判断する.
主な方法:
- 38人の健康で肥満の女性は3ヶ月のカロリー制限を受けました.
- 参加者は,安定状態の血糖 (SSPG) レベルに基づいて,インスリン抵抗性 (IR) またはインスリン感受性グループに分類されました.
- 血CRP濃度は,介入前と後に測定されました.
主要な成果:
- インスリン抵抗性の個人は,インスリンに敏感な個人に比べて,ベースラインのCRPレベルが著しく高かった.
- CRPとインスリン反応との間に有意な相関が認められたが,BMIや腰周量との相関は認められなかった.
- 体重減少は,IRグループでのみSSPGとCRPの有意な減少につながりました.
結論:
- CRP濃度は主にインスリン抵抗性のある肥満の個体で上昇しています.
- CRPとインスリン抵抗性の関係は,肥満とは無関係です.
- 体重減少とインスリン感受性の改善は,CRPレベルの低下と関連しています.
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