ヒトにおける心房中枢節への左心房の入力を示す
Mario D Gonzalez1, Leonardo J Contreras, Francisco Cardona
1Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0277, USA. gonzamd@medicine.ufl.edu
Circulation
|December 4, 2002
まとめ
mitra annulusは,ヒトにおける心房 (AV) 節の左心房活性化のための重要な経路である. この研究は,AVノードへの左心房の入力について明らかにし,心臓の電気生理学の理解を進める.
科学分野:
- 心臓病学 心臓病学
- 心臓電気生理学 心臓電気生理学
- 人間の生理学 人間生理学
背景:
- 心房中枢 (AV) 節は,前後両方の右心房刺激から入力を受けます.
- AVノードへの左心房活性化経路を理解することは,心臓伝導を理解するために重要です.
研究 の 目的:
- ヒトの左心房からAVノードへの電気活性化の経路を調査する.
主な方法:
- 右心房と左心房 (冠動脈鼻腔) の刺激を用いて,正常な心臓を持つ46人の患者でAV結節伝導を研究した.
- A-H間隔を測定し,様々なペースプロトコルでHの束の近くの心房電図を分析しました.
- アクティベーションのタイミングを評価するために,異なる場所での遅い心房外刺激を利用した.
主要な成果:
- 左心房刺激により,右心房刺激 (73 ms vs. 99 ms) と比較して,A-H間隔が著しく短くなった.
- Inferoparaseptal mitral annulusでの刺激は,左側の入力を示し,心房と彼の束の活性化の両方を前進させました.
- 前頭と後頭のアプローチからの外刺激は,ミトラアヌルスの刺激とは異なり,His バンドルの活性化時間を変化させなかった.
結論:
- mitra annulus は,ヒトの AV ノードへの重要な左心房の入力部位として機能します.
- この発見は,心臓の電気伝導におけるこれまであまり理解されていない経路を明らかにしています.
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