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Updated: Jul 18, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

溶性エポキシードヒドロラーゼの反応機構:分子動力学シミュレーションからの洞察

Birgit Schiøtt1, Thomas C Bruice

  • 1Department of Chemistry, Aarhus University, 8000 Aarhus, Denmark. birgit@chem.au.dk

Journal of the American Chemical Society
|December 6, 2002
PubMed
まとめ

分子動力学シミュレーションにより,溶性エポキシドヒドローラゼ (sEH) がどのように反応を触媒化するかが明らかになりました. 陽子化ヒスティジンは活性部位の安定性にとって不可欠であり,Tyr465は水素結合を通じて基板の地域選択性を導きます.

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For instance, the decomposition of ozone appears to follow a mechanism with two steps:
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Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

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Heterogeneous Catalysis

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