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Updated: Jul 7, 2026

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
14:27

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity

Published on: August 19, 2013

ヌクレオシドヒドロラーゼ触媒を in silico で探求する:酵素結合基板と移行状態の分子動力学的研究

Devleena Mazumder1, Thomas C Bruice

  • 1Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.

Journal of the American Chemical Society
|December 6, 2002
PubMed
まとめ

分子ダイナミクスシミュレーションでは,His241ではなく,Tyr229が,イノシン-ウリジン核酸ヒドロラーゼの陽子源として作用することを示しています. His241Ala変異は,この重要な水素結合ネットワークを破壊し,酵素の活性を低下させます.

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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion09:17

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Published on: March 1, 2022

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