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RNAアプタマーに結合すると,マラキット緑の電荷分布と形状が変化します

Dat H Nguyen1, Steven C DeFina, William H Fink

  • 1Department of Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.

Journal of the American Chemical Society
|December 12, 2002
PubMed
まとめ

この研究は,RNAアプタマーに結合する小分子が構造変化を経験し,リガンドが硬い標的であるという見解に異議を唱えていることを明らかにしています. この誘発的フィットメカニズムは,効果的なRNAベースの治療法の設計に不可欠です.

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