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Updated: May 22, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 16, 2010

HIV-1は,受容体結合部位の構成マスク化により,抗体媒介による中和を回避する

Peter D Kwong1, Michael L Doyle, David J Casper

  • 1Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA. pdkwong@nih.gov

Nature
|December 13, 2002
PubMed
まとめ

ヒト免疫不全ウイルス (HIV-1) は,その封筒グリコプロテイン (gp120) のコンフォメーションマスクを通して抗体の中和を回避します. このメカニズムにより,ウイルスは抗体攻撃に抵抗しながら受容体に結合し,持続的な感染とエイズに寄与します.

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