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Updated: May 12, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Sam68のリン酸化によるスプライシングの信号依存的調節

Nathalie Matter1, Peter Herrlich, Harald König

  • 1Forschungszentrum Karlsruhe GmbH, Institut für Toxikologie und Genetik, Postfach 3640, D-76021 Karlsruhe, Germany.

Nature
|December 13, 2002
PubMed
まとめ

この研究は,細胞外信号によって調節されるSam68タンパク質の改変が,代替スプライシングを制御することを明らかにしています. このメカニズムは,信号伝導経路と遺伝子発現の複雑さを結びつける.

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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