セルラー・シグナリング・アライアンスの概要
Alfred G Gilman1, Melvin I Simon, Henry R Bourne
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Nature
|December 13, 2002
まとめ
アライアンス・フォー・セルラー・シグナリングは,セルラー通信ネットワークの地図を作成しています. この研究は,免疫Bリンパ球と心筋筋細胞に焦点を当て,定量モデリングを進めて,グローバルな科学的発見のためにデータをオープンに共有します.
科学分野:
- 細胞生物学 細胞生物学
- システム生物学 システム生物学
- 免疫学 免疫学とは
- 心臓病学 心臓病学
背景:
- 細胞信号伝達ネットワークは,生物学的プロセスにとって根本的なものです.
- これらのネットワークを理解することは,世界の健康上の課題に取り組む上で極めて重要です.
- 以前の研究はしばしば断片化され,包括的な分析を制限していました.
研究 の 目的:
- セルラー信号伝達経路の調査のための大規模な協力を確立する.
- 信号ネットワークの定量モデリングを容易にする.
- データを自由に利用できるようにすることで,補完的な研究を促進する.
主な方法:
- 2つの主要な細胞タイプであるBリンパ球と心筋細胞における信号伝達経路の集中的な研究.
- 定量モデリングのアプローチの適用.
- データ共有インフラストラクチャの構築.
主要な成果:
- セルラー信号データの包括的なリソースの開発.
- Bリンパ球と心筋細胞における重要なシグナル伝達経路の特定.
- オープンデータアクセスを通じて学際的な研究を促進する.
結論:
- The Alliance for Cellular Signalingは,複雑な信号ネットワークを理解するための強力な枠組みを提供します.
- オープンデータへのアクセスは,科学的発見と共同研究を加速します.
- このイニシアチブは,細胞生物学,免疫学,心臓学を大幅に進歩させる可能性を秘めています.
関連する概念動画
Cell-surface Signaling
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Diversity in Cell Signaling Responses
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...


