アミロイド繊維のダイナミクスと流動性:繊維タンパク質集積物のモデル

Ami S Lakdawala1, David M Morgan, Dennis C Liotta

  • 1Center for the Analysis of Supramolecular Self-assemblies, Department of Chemistry, Department of Chemistry, Emory University, 1521 Pierce Drive, Atlanta, Georgia 30322, USA.

PubMed
まとめ

分子ダイナミクスシミュレーションにより,アルツハイマー病の研究において極めて重要なβ-アミロイド (Abeta) 線維のダイナミックな性質が明らかになりました. 暫定的な水素結合と内部溶解は,これらのアミロイド構造の安定に寄与する.

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